| http://purl.uniprot.org/citations/25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25501580 | http://www.w3.org/2000/01/rdf-schema#comment | "Asthma-related mortality has been decreasing due to inhaled corticosteroid use, but severe asthma remains a major clinical problem. One characteristic of severe asthma is resistance to steroid therapy, which is related to neutrophilic inflammation. Recently, the tumor necrosis factor superfamily member (TNFSF) 14/LIGHT has been recognized as a key mediator in severe asthmatic airway inflammation. However, the profiles and intracellular mechanisms of cytokine/chemokine production induced in cells by LIGHT are poorly understood. We aimed to elucidate the molecular mechanism of LIGHT-induced cytokine/chemokine production by bronchial epithelial cells. Human bronchial epithelial cells express lymphotoxin β receptor (LTβR), but not herpesvirus entry mediator, which are receptors for LIGHT. LIGHT induced various cytokines/chemokines, such as interleukin (IL)-6, oncostatin M, monocyte chemotactic protein-1, growth-regulated protein α and IL-8. Specific siRNA for LTβR attenuated IL-6 and IL-8 production by BEAS-2B and normal human bronchial epithelial cells. LIGHT activated intracellular signaling, such as mitogen-activated protein kinase and nuclear factor-κB (NF-κB) signaling. LIGHT also induced luciferase activity of NF-κB response element, but not of activator protein-1 or serum response element. Specific inhibitors of phosphorylation of extracellular signal-regulated kinase (Erk) and that of inhibitor κB attenuated IL-8 production, suggesting that LIGHT-LTβR signaling induces IL-8 production via the Erk and NF-κB pathways. LIGHT, via LTβR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0114791"xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Horie M."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Mikami Y."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Nagase T."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Noguchi S."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Matsuzaki H."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Takizawa H."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Jo T."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Narumoto O."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/author | "Kohyama T."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/pages | "e114791"xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/title | "Lymphotoxin beta receptor signaling induces IL-8 production in human bronchial epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25501580 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25501580 |
| http://purl.uniprot.org/citations/25501580 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25501580 |
| http://purl.uniprot.org/uniprot/#_B3KTD9-mappedCitation-25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501580 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4P8-mappedCitation-25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501580 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501580 |
| http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501580 |
| http://purl.uniprot.org/uniprot/#_O43557-mappedCitation-25501580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25501580 |