| http://purl.uniprot.org/citations/25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25503409 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor p63 (Trp63) plays a key role in homeostasis and regeneration of the skin. The p63 gene is transcribed from dual promoters, generating TAp63 isoforms with growth suppressive functions and dominant-negative ΔNp63 isoforms with opposing properties. p63 also encodes multiple carboxy (C)-terminal variants. Although mutations of C-terminal variants have been linked to the pathogenesis of p63-associated ectodermal disorders, the physiological role of the p63 C-terminus is poorly understood. We report here that deletion of the p63 C-terminus in mice leads to ectodermal malformation and hypoplasia, accompanied by a reduced proliferative capacity of epidermal progenitor cells. Notably, unlike the p63-null condition, we find that p63 C-terminus deficiency promotes expression of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1) (Cdkn1a), a factor associated with reduced proliferative capacity of both hematopoietic and neuronal stem cells. These data suggest that the p63 C-terminus plays a key role in the cell cycle progression required to maintain the proliferative potential of stem cells of many different lineages. Mechanistically, we show that loss of Cα, the predominant C-terminal p63 variant in epithelia, promotes the transcriptional activity of TAp63 and also impairs the dominant-negative activity of ΔNp63, thereby controlling p21(Waf1/Cip1) expression. We propose that the p63 C-terminus links cell cycle control and the proliferative potential of epidermal progenitor cells via mechanisms that equilibrate TAp63 and ΔNp63 isoform function."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.118307"xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/author | "Suzuki D."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/author | "Senoo M."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/author | "Sahu R."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/author | "Leu N.A."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/pages | "282-290"xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/title | "The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells."xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/25503409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25503409 |
| http://purl.uniprot.org/citations/25503409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25503409 |
| http://purl.uniprot.org/uniprot/O88898#attribution-68ED0426F383241D17B00751C617E9C4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_D3Z7K2-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_P70677-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRX1-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1K8-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A140LJ83-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A140LJA8-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A2A513-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSR7-mappedCitation-25503409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25503409 |