| http://purl.uniprot.org/citations/25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25510212 | http://www.w3.org/2000/01/rdf-schema#comment | "Human β-defensin-2(HBD-2) is one of the two major vertebrate antimicrobial peptide families (α and β), which is highly expressed by proinflammatory induction in the lung and exhibit broad-spectrum antimicrobial activity. We observed that IL-22 receptors high expressed on the membrane of A549 cells; HBD-2 mRNA was expressed in a time- and concentration-dependent manners in A549 cells when treated with IL-22; further studies demonstrated that HBD-2 expression was attenuated by AG490, but to JSH-23, inhibitors of p-STAT3 DNA binding and NF-κB/p65 subunit nuclear translocation, respectively. These results support that IL-22-mediated signalling pathway of HBD-2 gene expression involved STAT3 but not NF-κB in human alveolar epithelium. These findings provide a new insight into how IL-22 may play an important link between innate and adaptive immunity, thereby anti-infection locally in the alveolar epithelium."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10753-014-0083-z"xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Cui X."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Li A."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Gan Y."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/author | "Ma T."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/name | "Inflammation"xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/pages | "1191-1200"xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/title | "IL-22 Up-Regulates beta-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-kappaB Signaling Pathway."xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/25510212 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25510212 |
| http://purl.uniprot.org/citations/25510212 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25510212 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C389-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_B4DNP0-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_B4DVR6-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_B5BTZ6-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_P40763-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |
| http://purl.uniprot.org/uniprot/#_Q6NZ83-mappedCitation-25510212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25510212 |