| http://purl.uniprot.org/citations/25512391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25512391 | http://www.w3.org/2000/01/rdf-schema#comment | "The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length. In this paper, we identify a counteracting system in which PP2A-B56γ and -ε, but not PP2A-B56α, -β, and -δ, are maintained at the central spindle by KIF4A. Biochemical assays show that PP2A-B56γ can dephosphorylate the T799 Aurora B site on KIF4A and thereby counteract the Aurora B- and microtubule-stimulated ATPase activity of KIF4A. In agreement with these observations, combined silencing of PP2A-B56γ and -ε resulted in increased phosphorylation of KIF4A T799 and decreased central spindle growth in anaphase B. Furthermore, reduced turnover of regulatory phosphorylation on another Aurora B substrate MKlp1 was observed, suggesting that PP2A-B56γ and -ε play a general role opposing Aurora B at the central spindle. KIF4A and PP2A-B56γ and -ε therefore create a spatially restricted negative feedback loop counteracting Aurora B in anaphase."xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201409129"xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/author | "Barr F.A."xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/author | "Cundell M.J."xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/author | "Bastos R.N."xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/pages | "683-693"xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/title | "KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle."xsd:string |
| http://purl.uniprot.org/citations/25512391 | http://purl.uniprot.org/core/volume | "207"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q562F2-mappedCitation-25512391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25512391 |