| http://purl.uniprot.org/citations/25514038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25514038 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25514038 | http://www.w3.org/2000/01/rdf-schema#comment | "PTRF/cavin-1 is a protein of two lives. Its reported functions in ribosomal RNA synthesis and in caveolae formation happen in two different cellular locations: nucleus vs. plasma membrane. Here, we identified that the N-terminal leucine-zipper motif in PTRF/cavin-1 was essential for the protein to be associated with caveolae in plasma membrane. It could counteract the effect of nuclear localization sequence in the molecule (AA 235-251). Deletion of this leucine-zipper motif from PTRF/cavin-1 caused the mutant to be exclusively localized in nuclei. The fusion of this leucine-zipper motif with histone 2A, which is a nuclear protein, could induce the fusion protein to be exported from nucleus. Cell migration was greatly inhibited in PTRF/cavin-1(-/-) mouse embryonic fibroblasts (MEFs). The inhibited cell motility could only be rescued by exogenous cavin-1 but not the leucine-zipper motif deleted cavin-1 mutant. Plasma membrane dynamics is an important factor in cell motility control. Our results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.12.035"xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2014.12.035"xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wei Z."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wei Z."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Liao K."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Liao K."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Zou X."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/author | "Zou X."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/pages | "750-756"xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/pages | "750-756"xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/title | "The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association."xsd:string |
| http://purl.uniprot.org/citations/25514038 | http://purl.uniprot.org/core/title | "The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association."xsd:string |