| http://purl.uniprot.org/citations/25514089 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25514089 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide-2 (GLP-2) is an enteroendocrine hormone that stimulates the growth of the intestinal epithelium. We have previously demonstrated that GLP-2 exerts its intestinotropic effect through an indirect mechanism that requires both IGF-1 and the intestinal epithelial IGF-1 receptor. However, the biological activity of IGF-1 is modulated by IGF binding proteins (IGFBPs), including IGFBP-4, which is highly expressed in the intestine. To determine the role of IGFBP-4 in the tropic effects of GLP-2, IGFBP-4 knockout (KO) and control mice were treated with degradation-resistant GLP-2 or vehicle for 10 days. Comparable levels of IGFBP-1-3/5-7 mRNAs were observed in the intestinal mucosa of all animals. IGFBP-4 KO mice had greater small intestinal weight and length, and deeper crypts (P < .05) as compared with controls, suggesting that IGFBP-4 has an inhibitory role in basal intestinal growth. However, small intestinal weight, crypt-villus height and crypt cell proliferation increased in response to GLP-2 in control mice (P < .05), and these changes were abrogated with IGFBP-4 KO. In contrast, pregnancy-associated plasma protein-A KO mice, which have increased levels of circulating IGFBP-4, demonstrated a normal intestinotropic response to GLP-2. Finally, GLP-2 treatment of control mice significantly increased IGFBP-4 mRNA expression in the jejunal mucosa (P < .05), a finding that was recapitulated by GLP-2 treatment of fetal rat intestinal cells in culture (10(-8)M for 2 h; P < .05). Collectively, these results indicate that the IGF-I-modulating protein, IGFBP-4, exerts a negative effect on basal intestinal growth but plays a positive regulatory role in the intestinotropic actions of GLP-2."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2014-1829"xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/author | "Pintar J.E."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/author | "Brubaker P.L."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/author | "Austin K."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/author | "Imam N.A."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/pages | "429-436"xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/title | "IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine."xsd:string |
| http://purl.uniprot.org/citations/25514089 | http://purl.uniprot.org/core/volume | "156"xsd:string |
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