| http://purl.uniprot.org/citations/25515760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25515760 | http://www.w3.org/2000/01/rdf-schema#comment | "Orexins are hypothalamic peptides that regulate food intake, wakefulness, the reward system and energy metabolism. Recent studies have demonstrated the ability of orexins to promote a robust apoptosis and subsequent inhibition of cell growth in various types of cancer cells. The present study was conducted to investigate the effects of orexin A on the survival of human gastric cancer cells, SGC‑7901, and the possible mechanisms. SGC‑7901 cells were exposed to various concentrations of orexin A in vitro in the presence or absence of the orexin receptor 1 (OX1R) antagonist (SB334867), extracellular signal‑regulated kinases 1 and 2 (ERK1/2) antagonist (U0126) or a combination of the two antagonists. The amount of cell proliferation, viability and apoptosis, caspase‑8 and caspases‑9 activities, OX1R protein expression and ERK1/2 protein levels were determined. The expression of OX1R in SGC‑7901 cells was observed. Orexin A (10-10 to 10-6 M) stimulated SGC‑7901 cell proliferation and viability, reduced the pro‑apoptotic activity of caspase‑9 and protected the cells from apoptosis in a dose‑dependent manner. Additionally, ERK1/2 phosphorylation was stimulated by orexin A (10-10 to 10-6 M). However, the OX1R antagonist SB334867 (10-6 M), ERK1/2 antagonist U0126 (30 µM) or the combination of antagonists blocked the effects of orexin A to a certain extent. These results suggest that stimulation of OX1R induces the growth of SGC‑7901 gastric cancer cells through activation of ERK1/2 signaling pathway. These findings add a new dimension to the biological activities of orexin, which may have important implications in health and disease, in particular gastric cancer."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijmm.2014.2038"xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/author | "Guo L."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/author | "Ju S."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/name | "Int J Mol Med"xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/pages | "539-545"xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/title | "Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/25515760 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25515760 |
| http://purl.uniprot.org/citations/25515760 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25515760 |
| http://purl.uniprot.org/uniprot/#_A6NMV7-mappedCitation-25515760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25515760 |
| http://purl.uniprot.org/uniprot/#_O43612-mappedCitation-25515760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25515760 |
| http://purl.uniprot.org/uniprot/#_O43613-mappedCitation-25515760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25515760 |
| http://purl.uniprot.org/uniprot/O43613 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25515760 |
| http://purl.uniprot.org/uniprot/A6NMV7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25515760 |
| http://purl.uniprot.org/uniprot/O43612 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25515760 |