| http://purl.uniprot.org/citations/25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25518934 | http://www.w3.org/2000/01/rdf-schema#comment | "During hyperosmotic shock, Saccharomyces cerevisiae adjusts to physiological challenges, including large plasma membrane invaginations generated by rapid cell shrinkage. Calcineurin, the Ca(2+)/calmodulin-dependent phosphatase, is normally cytosolic but concentrates in puncta and at sites of polarized growth during intense osmotic stress; inhibition of calcineurin-activated gene expression suggests that restricting its access to substrates tunes calcineurin signaling specificity. Hyperosmotic shock promotes calcineurin binding to and dephosphorylation of the PI(4,5)P2 phosphatase synaptojanin/Inp53/Sjl3 and causes dramatic calcineurin-dependent reorganization of PI(4,5)P2-enriched membrane domains. Inp53 normally promotes sorting at the trans-Golgi network but localizes to cortical actin patches in osmotically stressed cells. By activating Inp53, calcineurin repolarizes the actin cytoskeleton and maintains normal plasma membrane morphology in synaptojanin-limited cells. In response to hyperosmotic shock and calcineurin-dependent regulation, Inp53 shifts from associating predominantly with clathrin to interacting with endocytic proteins Sla1, Bzz1, and Bsp1, suggesting that Inp53 mediates stress-specific endocytic events. This response has physiological and molecular similarities to calcineurin-regulated activity-dependent bulk endocytosis in neurons, which retrieves a bolus of plasma membrane deposited by synaptic vesicle fusion. We propose that activation of Ca(2+)/calcineurin and PI(4,5)P2 signaling to regulate endocytosis is a fundamental and conserved response to excess membrane in eukaryotic cells."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e14-05-1019"xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/author | "Elias J.E."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/author | "Cyert M.S."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/author | "Guiney E.L."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/author | "Goldman A.R."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/pages | "769-785"xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/title | "Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 during membrane stress."xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25518934 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25518934 |
| http://purl.uniprot.org/citations/25518934 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25518934 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BW60-mappedCitation-25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/#_P25296-mappedCitation-25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/#_P23287-mappedCitation-25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/#_Q12271-mappedCitation-25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/#_P14747-mappedCitation-25518934 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/P25296 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/P23287 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/P14747 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/A0A8H4BW60 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25518934 |
| http://purl.uniprot.org/uniprot/Q12271 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25518934 |