| http://purl.uniprot.org/citations/25520399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25520399 | http://www.w3.org/2000/01/rdf-schema#comment | "Current subunit vaccines are incapable of inducing Ag-specific CD8(+) T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. In experimental vaccines, cytotoxic responses can be elicited by targeting of Ag into cross-presenting dendritic cells (DC), but almost all available systems use target molecules also expressed on other cells and thus lack the desired specificity. In the present work, we induced CD8(+) T cell cytotoxicity by targeting of Ag to XCR1, a chemokine receptor exclusively expressed on murine and human cross-presenting DC. Targeting of Ag with a mAb or the chemokine ligand XCL1 was highly specific, as determined with XCR1-deficient mice. When applied together with an adjuvant, both vector systems induced a potent cytotoxic response preventing the outgrowth of an inoculated aggressive tumor. By generating a transgenic mouse only expressing the human XCR1 on its cross-presenting DC, we could demonstrate that targeting of Ag using human XCL1 as vector is fully effective in vivo. The specificity and efficiency of XCR1-mediated Ag targeting to cross-presenting DC, combined with its lack of adverse effects, make this system a prime candidate for the development of therapeutic cytotoxic vaccines in humans."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1401903"xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Becker M."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Weise C."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Weber H."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Henn V."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Anastassiadis K."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Hartung E."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Kroczek R.A."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Mages H.W."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Hutloff A."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Giesecke C."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Bachem A."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Gurka S."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Jakel A."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/author | "Reeg N."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/pages | "1069-1079"xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/title | "Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1."xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/25520399 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25520399 |
| http://purl.uniprot.org/citations/25520399 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25520399 |
| http://purl.uniprot.org/uniprot/#_A0A4D6YMW1-mappedCitation-25520399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25520399 |