| http://purl.uniprot.org/citations/25521228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25521228 | http://www.w3.org/2000/01/rdf-schema#comment | "Human genetic susceptibility for tuberculosis (TB) has been demonstrated by several studies, but few have examined the multiple innate and adaptive immunity genes comprehensively, age-specific effects and/or resistance to Mycobacterium tuberculosis (Mtb) infection (resistors (RSTRs)). We hypothesized that RSTRs, defined by a persistently negative tuberculin skin test, may have different genetic influences than Mtb disease. We examined 29 candidate genes in pathways that mediate immune responses to Mtb in subjects in a household contact study in Kampala, Uganda. We genotyped 546 haplotype-tagging single-nucleotide polymorphisms (SNPs) in 835 individuals from 481 families; 28.7% had TB, 10.5% were RSTRs, and the remaining 60.8% had latent Mtb infection. Among our most significant findings were SNPs in TICAM2 (P = 3.6 × 10(-6)) and IL1B (P = 4.3 × 10(-5)) associated with TB. Multiple SNPs in IL4 and TOLLIP were associated with TB (P < 0.05). Age-genotype interaction analysis revealed SNPs in IL18 and TLR6 that were suggestively associated with TB in children aged ⩽ 10 years (P = 2.9 × 10(-3)). By contrast, RSTR was associated with SNPs in NOD2, SLC6A3 and TLR4 (nominal P < 0.05); these genes were not associated with TB, suggesting distinct genetic influences. We report the first association between TICAM2 polymorphisms and TB and between IL18 and pediatric TB."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.org/dc/terms/identifier | "doi:10.1038/gene.2014.77"xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Tao L."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Boom W.H."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Igo R.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Stein C.M."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Joloba M.L."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Hawn T.R."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Schnell A."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Lancioni C."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Mayanja-Kizza H."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Chervenak K."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Malone L.L."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Nsereko M."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Truitt B."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Hall N.B."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/author | "Okware B."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/pages | "127-133"xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/title | "Polymorphisms in TICAM2 and IL1B are associated with TB."xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/25521228 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25521228 |
| http://purl.uniprot.org/citations/25521228 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25521228 |