| http://purl.uniprot.org/citations/2552292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2552292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2552292 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae strains are often host to several types of cytoplasmic double-stranded RNA (dsRNA) genomes, some of which are encapsidated by the L-A dsRNA product, an 86,000-dalton coat protein. Here we present the finding that nuclear recessive mutations in the NUC1 gene, which encodes the major nonspecific nuclease of yeast mitochondria, resulted in at least a 10-fold increase in amounts of the L-A dsRNA and its encoded coat protein. The effect of nuc1 mutations on L-A abundance was completely suppressed in strains that also hosted the killer-toxin-encoding M dsRNA. Both NUC1 and nuc1 strains containing the L-A genome exhibited an increase in coat protein abundance and a concomitant increase in L-A dsRNA when the cells were grown on a nonfermentable carbon source rather than on glucose, an effect independent of the increase in coat protein due to nuc1 mutations or to the absence of M. The increase in L-A expression in nuc1 strains was similar to that observed in strains with mutations in the nuclear gene encoding the most abundant outer mitochondrial membrane protein, porin. nuc1 mutations did not affect the level of porin in the mitochondrial outer membrane. Since the effect of mutations in nuc1 was to alter the copy number of the L-A coat protein genome rather than to change the level of the M toxin genome (as do mak and ski mutations), these mutations define a new class of nuclear genes affecting yeast dsRNA abundance."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.9.8.3323-3331.1989"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.9.8.3323-3331.1989"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/author | "Dieckmann C.L."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/author | "Dieckmann C.L."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/pages | "3323-3331"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/pages | "3323-3331"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/title | "Overproduction of yeast viruslike particles by strains deficient in a mitochondrial nuclease."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/title | "Overproduction of yeast viruslike particles by strains deficient in a mitochondrial nuclease."xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/2552292 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2552292 |
| http://purl.uniprot.org/citations/2552292 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2552292 |
| http://purl.uniprot.org/citations/2552292 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2552292 |
| http://purl.uniprot.org/citations/2552292 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2552292 |
| http://purl.uniprot.org/uniprot/P08466 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2552292 |
| http://purl.uniprot.org/uniprot/P07252 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2552292 |