| http://purl.uniprot.org/citations/25525152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25525152 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25525152 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear exosome targeting complex (NEXT) directs a major 3'-5' exonuclease, the RNA exosome, for degradation of nuclear noncoding (nc) RNAs. We identified the RNA-binding component of the NEXT complex, RBM7, as a substrate of p38(MAPK)/MK2-mediated phosphorylation at residue S136. As a result of this phosphorylation, RBM7 displays a strongly decreased RNA-binding capacity, while inhibition of p38(MAPK) or mutation of S136A in RBM7 increases its RNA association. Interestingly, promoter-upstream transcripts (PROMPTs), such as proRBM39, proEXT1, proDNAJB4, accumulated upon stress stimulation in a p38(MAPK)/MK2-dependent manner, a process inhibited by overexpression of RBM7(S136A). While there are no stress-dependent changes in RNA-polymerase II (RNAPII) occupation of PROMPT regions representing unchanged transcription, stability of PROMPTs is increased. Hence, we propose that phosphorylation of RBM7 by the p38(MAPK)/MK2 axis increases nuclear ncRNA stability by blocking their RBM7-binding and subsequent RNA exosome targeting to allow stress-dependent modulations of the noncoding transcriptome."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.048090.114"xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.048090.114"xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Cohen P."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Cohen P."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Lubas M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Lubas M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Gaestel M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Gaestel M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Tehrani M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Tehrani M."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Tiedje C."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Tiedje C."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Rousseau S."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Rousseau S."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Menon M.B."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Menon M.B."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Kotlyarov A."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Kotlyarov A."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Ronkina N."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/author | "Ronkina N."xsd:string |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25525152 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |