| http://purl.uniprot.org/citations/25529012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25529012 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor cell stemness has been recognized as a key contributor to tumor initiation, progression and recurrence. Our previous studies have found that semaphorin-3F (SEMA3F), an axon guidance molecule in the development of central nervous system, inhibited the growth and metastasis of colorectal cancer (CRC). However, a possible role for SEMA3F in regulating cancer cell stemness remains unknown. Here, we report a novel mechanism of the acquirement of stemness of CRC cells regulated by SEMA3F. Knockdown of SEMA3F significantly promoted the self-renewal and tumorigenicity of CRC cells, and increased the expression of stemness-associated genes, while overexpressing SEMA3F reduced the stemness of CRC cells. Mechanistically, GTP-Rac1 was involved in SEMA3F mediated regulation of CRC cell stemness by targeting the Wnt/β-catenin pathway. Clinically, GTP-Rac1 expression was inversely correlated with SEMA3F levels in CRC samples and patients with SEMA3F(low)/GTP-Rac1(high) CRC showed poorer prognosis. Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for CRC."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.canlet.2014.12.040"xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Wu F."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Wang B."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Xu S.L."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Zhou Z.H."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Rao J."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Cui Y.H."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Bian X.W."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/author | "Ping Y.F."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/name | "Cancer Lett"xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/pages | "76-84"xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/title | "Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1."xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://purl.uniprot.org/core/volume | "358"xsd:string |
| http://purl.uniprot.org/citations/25529012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25529012 |
| http://purl.uniprot.org/citations/25529012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25529012 |
| http://purl.uniprot.org/uniprot/#_C9JPG5-mappedCitation-25529012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25529012 |
| http://purl.uniprot.org/uniprot/#_Q13275-mappedCitation-25529012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25529012 |
| http://purl.uniprot.org/uniprot/#_Q59G50-mappedCitation-25529012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25529012 |