| http://purl.uniprot.org/citations/25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25533348 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of a G1/S regulon of genes that are required for DNA replication is a ubiquitous mechanism for controlling cell proliferation; moreover, the pathological deregulated expression of E2F-regulated G1/S genes is found in every type of cancer. Cellular tolerance of deregulated G1/S transcription is surprising because this regulon includes many dosage-sensitive proteins. Here, we used the fission yeast Schizosaccharomyces pombe to investigate this issue. We report that deregulating the MBF G1/S regulon by eliminating the Nrm1 corepressor increases replication errors. Homology-directed repair proteins, including MBF-regulated Ctp1(CtIP), are essential to prevent catastrophic genome instability. Surprisingly, the normally inconsequential MBF-regulated S-phase cyclin Cig2 also becomes essential in the absence of Nrm1. This requirement was traced to cyclin-dependent kinase inhibition of the MBF-regulated Cdc18(Cdc6) replication origin-licensing factor. Collectively, these results establish that, although deregulation of G1/S transcription is well tolerated by cells, nonessential G1/S target genes become crucial for preventing catastrophic genome instability."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.11.039"xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Limbo O."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Russell P."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Dovey C."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Klier S."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "de Bruin R.A."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Farmer S."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/author | "Caetano C."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/pages | "2279-2289"xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/title | "Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability."xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25533348 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25533348 |
| http://purl.uniprot.org/citations/25533348 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25533348 |
| http://purl.uniprot.org/uniprot/P34208#attribution-49942AD703499421CE9509B79A9E1EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/P30290#attribution-49942AD703499421CE9509B79A9E1EED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/O42913#attribution-75892DB63EEEAF7CBDDA8FCF449013BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/#_O42913-mappedCitation-25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/#_P41412-mappedCitation-25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/#_P40923-mappedCitation-25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/#_P33520-mappedCitation-25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25533348 |
| http://purl.uniprot.org/uniprot/#_P36630-mappedCitation-25533348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25533348 |