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| http://purl.uniprot.org/citations/25535083 | http://www.w3.org/2000/01/rdf-schema#comment | "During maturation, tRNA molecules undergo a series of individual processing steps, ranging from exo- and endonucleolytic trimming reactions at their 5'- and 3'-ends, specific base modifications and intron removal to the addition of the conserved 3'-terminal CCA sequence. Especially in mitochondria, this plethora of processing steps is completed by various editing events, where base identities at internal positions are changed and/or nucleotides at 5'- and 3'-ends are replaced or incorporated. In this review, we will focus predominantly on the latter reactions, where a growing number of cases indicate that these editing events represent a rather frequent and widespread phenomenon. While the mechanistic basis for 5'- and 3'-end editing differs dramatically, both reactions represent an absolute requirement for generating a functional tRNA. Current in vivo and in vitro model systems support a scenario in which these highly specific maturation reactions might have evolved out of ancient promiscuous RNA polymerization or quality control systems."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms151223975"xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/author | "Long Y."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/author | "Jackman J.E."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/author | "Betat H."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/author | "Morl M."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/pages | "23975-23998"xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/title | "From end to end: tRNA editing at 5'- and 3'-terminal positions."xsd:string |
| http://purl.uniprot.org/citations/25535083 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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