| http://purl.uniprot.org/citations/25535736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25535736 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-34 (IL-34) is a newly discovered cytokine as an additional ligand for colony stimulating factor-1 receptor (CSF1R), and its functions are expected to overlap with colony stimulating factor-1/macrophage-colony stimulating factor. We have previously shown that the IL-34 is primarily produced by neurons in the central nervous system (CNS) and induces proliferation and neuroprotective properties of microglia which express CSF1R. However, the functions of IL-34 in the CNS are still elucidative. Here we show that CNS capillary endothelial cells also express CSF1R. IL-34 protected blood-brain barrier integrity by restored expression levels of tight junction proteins, which were downregulated by pro-inflammatory cytokines. The novel function of IL-34 on the blood-brain barrier may give us a clue for new therapeutic strategies in neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0115981"xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Horiuchi H."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Takeuchi H."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Kawanokuchi J."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Sonobe Y."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/author | "Suzumura A."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/pages | "e115981"xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/title | "Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/25535736 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25535736 |
| http://purl.uniprot.org/citations/25535736 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25535736 |
| http://purl.uniprot.org/uniprot/#_Q8R1R4-mappedCitation-25535736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25535736 |
| http://purl.uniprot.org/uniprot/Q8R1R4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25535736 |