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http://purl.uniprot.org/citations/25536158http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25536158http://www.w3.org/2000/01/rdf-schema#comment"

Background

Two common clinical syndromes of acetylsalicylic acid (aspirin) hypersensitivity, aspirin-exacerbated respiratory disease (AERD) and aspirin-exacerbated cutaneous disease (AECD), were subjected to a genome-wide association study to identify strong genetic markers for aspirin hypersensitivity in a Korean population.

Methods

A comparison of SNP genotype frequencies on an Affymetrix Genome-Wide Human SNP array of 179 AERD patients and 1989 healthy normal control subjects (NC) revealed SNPs on chromosome 6 that were associated with AERD, but not AECD. To validate the association, we enrolled a second cohort comprising AERD (n = 264), NC (n = 238) and disease-control (aspirin tolerant asthma; ATA, n = 387) groups.

Results

The minor genotype frequency (AG or AA) of a particular SNP, rs3128965, in the HLA-DPB1 region was higher in the AERD group compared to the ATA or NC group (P = 0.001, P = 0.002, in a co-dominant analysis model, respectively). Comparison of rs3128965 alleles with the clinical features of asthmatics revealed that patients harboring the A allele had increased bronchial hyperresponsiveness to inhaled aspirin and methacholine, and higher 15-HETE levels, than those without the A allele (P = 0.039, 0.037, and 0.004, respectively).

Conclusions

This implies the potential of rs3128965 as a genetic marker for diagnosis and prediction of the AERD phenotype."xsd:string
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http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Choi H."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Park H.S."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Lee J.E."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Ye Y.M."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Shin E.S."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/author"Cho B.Y."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/pages"e111220"xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/title"The SNP rs3128965 of HLA-DPB1 as a genetic marker of the AERD phenotype."xsd:string
http://purl.uniprot.org/citations/25536158http://purl.uniprot.org/core/volume"9"xsd:string
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