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| http://purl.uniprot.org/citations/2553705 | http://www.w3.org/2000/01/rdf-schema#comment | "In order to analyze the complex activities of histamine H2 receptor activation on neutrophils, human HL-60 promyelocytic leukemia cells were differentiated into neutrophils by incubation with dimethyl sufoxide, loaded with the Ca2+-sensitive indicator dyes, indo-1 or fura-2, and the levels of intracellular Ca2+ ([Ca2+]i) measured in a fluorescent-activated cell sorter and fluorimeter, respectively. Histamine increased [Ca2+]i in a dose-dependent manner with a half-maximal concentration (EC50) of approximately 10(-6) to 10(-5) M, which exhibited H2 receptor specificity. Prostaglandin E2 and isoproterenol also induced [Ca2+]i mobilization in HL-60 cells, whereas the cell permeable form of cAMP and forskolin failed to increase [Ca2+]i. Since H2-receptor mediated [Ca2+]i mobilization was not inhibited by reducing the concentration of extracellular Ca2+ nor by the addition of Ca2+ channel antagonists, LaCl3 and nifedipine, [Ca2+]i mobilization is due to the release of Ca2+ from intracellular stores. Furthermore, both 10(-4) M histamine and 10(-6) M fMet-Leu-Phe increased the levels of 1,4,5-inositol trisphosphate. However, histamine-induced mobilization of [Ca2+]i was inhibited by cholera toxin but not by pertussis toxin, whereas the action of fMet-Leu-Phe was inhibited by pertussis toxin but not by cholera toxin. These data suggest that H2 receptors on HL-60 cells are coupled to two different cholera toxin-sensitive G-proteins and activate adenylate cyclase and phospholipase C simultaneously."xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)51471-x"xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/author | "Payan D.G."xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/author | "Mitsuhashi T."xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/author | "Mitsuhashi M."xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/pages | "18356-18362"xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/title | "Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/2553705 | http://purl.uniprot.org/core/volume | "264"xsd:string |
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