| http://purl.uniprot.org/citations/25547115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25547115 | http://www.w3.org/2000/01/rdf-schema#comment | "PTEN [phosphatidylinositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a phosphatase and critical tumor suppressor, is regulated by numerous post-translational modifications, including phosphorylation, ubiquitination, acetylation, and SUMOylation, which affect PTEN localization and protein stability. Here we report ADP-ribosylation as a new post-translational modification of PTEN. We identified PTEN as a novel substrate of tankyrases, which are members of the poly(ADP-ribose) polymerases (PARPs). We showed that tankyrases interact with and ribosylate PTEN, which promotes the recognition of PTEN by a PAR-binding E3 ubiquitin ligase, RNF146, leading to PTEN ubiquitination and degradation. Double knockdown of tankyrase1/2 stabilized PTEN, resulting in the subsequent down-regulation of AKT phosphorylation and thus suppressed cell proliferation and glycolysis in vitro and tumor growth in vivo. Furthermore, tankyrases were up-regulated and negatively correlated with PTEN expression in human colon carcinomas. Together, our study revealed a new regulation of PTEN and highlighted a role for tankyrases in the PTEN-AKT pathway that can be explored further for cancer treatment."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.251785.114"xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Liang K."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Lin C."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/author | "Songyang Z."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/pages | "157-170"xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/title | "Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth."xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/25547115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25547115 |
| http://purl.uniprot.org/citations/25547115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25547115 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-25547115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25547115 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-25547115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25547115 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-25547115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25547115 |