| http://purl.uniprot.org/citations/25552416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25552416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25552416 | http://www.w3.org/2000/01/rdf-schema#comment | "Zinc is essential for biological systems, and aberrant zinc metabolism is implicated in a broad range of human diseases. To maintain homeostasis in response to fluctuating levels of dietary zinc, animals regulate gene expression; however, mechanisms that mediate the transcriptional response to fluctuating levels of zinc have not been fully defined. Here, we identified DNA enhancer elements that mediate intestine-specific transcriptional activation in response to high levels of dietary zinc in C. elegans. Using bioinformatics, we characterized an evolutionarily conserved enhancer element present in multiple zinc-inducible genes, the high zinc activation (HZA) element. The HZA was consistently adjacent to a GATA element that mediates expression in intestinal cells. Functional studies using transgenic animals demonstrated that this modular system of DNA enhancers mediates tissue-specific transcriptional activation in response to high levels of dietary zinc. We used this information to search the genome and successfully identified novel zinc-inducible genes. To characterize the mechanism of enhancer function, we demonstrated that the GATA transcription factor ELT-2 and the mediator subunit MDT-15 are necessary for zinc-responsive transcriptional activation. These findings define new mechanisms of zinc homeostasis and tissue-specific regulation of transcription."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gku1360"xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gku1360"xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Zhao G."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Zhao G."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Deshmukh K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Deshmukh K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Roh H.C."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Roh H.C."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Cabrera D."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Cabrera D."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Dimitrov I."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Dimitrov I."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Tsai W."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Tsai W."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Warnhoff K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/author | "Warnhoff K."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |
| http://purl.uniprot.org/citations/25552416 | http://purl.uniprot.org/core/name | "Nucleic Acids Res."xsd:string |