| http://purl.uniprot.org/citations/25552599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25552599 | http://www.w3.org/2000/01/rdf-schema#comment | "Long-term use of glucocorticoids (GCs) causes numerous adverse effects, including glucose/lipid abnormalities, osteoporosis, and muscle wasting. The pathogenic mechanism, however, is not completely understood. In this study, we used plasminogen activator inhibitor-1 (PAI-1)-deficient mice to explore the role of PAI-1 in GC-induced glucose/lipid abnormalities, osteoporosis, and muscle wasting. Corticosterone markedly increased the levels of circulating PAI-1 and the PAI-1 mRNA level in the white adipose tissue of wild-type mice. PAI-1 deficiency significantly reduced insulin resistance and glucose intolerance but not hyperlipidemia induced by GC. An in vitro experiment revealed that active PAI-1 treatment inhibits insulin-induced phosphorylation of Akt and glucose uptake in HepG2 hepatocytes. However, this was not observed in 3T3-L1 adipocytes and C2C12 myotubes, indicating that PAI-1 suppressed insulin signaling in hepatocytes. PAI-1 deficiency attenuated the GC-induced bone loss presumably via inhibition of apoptosis of osteoblasts. Moreover, the PAI-1 deficiency also protected from GC-induced muscle loss. In conclusion, the current study indicated that PAI-1 is involved in GC-induced glucose metabolism abnormality, osteopenia, and muscle wasting in mice. PAI-1 may be a novel therapeutic target to mitigate the adverse effects of GC."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.org/dc/terms/identifier | "doi:10.2337/db14-1192"xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Chiba Y."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Okada K."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Tamura Y."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Kaji H."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Okumoto K."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Matsuo O."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/author | "Kawao N."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/pages | "2194-2206"xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/title | "Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice."xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/25552599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25552599 |
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| http://purl.uniprot.org/uniprot/#_P22777-mappedCitation-25552599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25552599 |
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