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| http://purl.uniprot.org/citations/25555372 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating evidence suggests that chemokine monocyte chemoattractant protein-1 (MCP-1) is significantly involved in the activation of spinal microglia associated with pathological pain, at the same time that the phosphatidylinositol 3-kinase/Protein Kinase B (PI3K/Akt) pathway localized in spinal microglia is involved in both neuropathic and inflammatory pain. However, whether there is a connection between MCP-1 and the PI3K/Akt pathway and in their underlying mechanisms in bone cancer pain (BCP) has not yet been elucidated. In the current study, we investigated the expression changes of p-Akt in microglia and OX-42 (microglia marker) after being stimulated with MCP-1 in vitro, as well as in a BCP model that was established by an intramedullary injection of mammary gland carcinoma cells(Walker 256 cells) into the tibia of rats. We observed a significant increase in expression levels of p-Akt and OX-42 in microglia as well as in spinal dorsal horns of BCP rats. Furthermore, the intrathecal administration of an anti-MCP-1 neutralizing antibody or PI3K inhibitor LY294002 reduced the expression of p-Akt or OX-42, and LY294002 attenuated the mechanical allodynia of BCP rats. These results suggest that MCP-1 may stimulate spinal microglia via the PI3K/Akt pathway in BCP."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2014.12.043"xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/author | "Jin D."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/author | "Yang J.P."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/author | "Hu J.H."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/author | "Wang L.N."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/author | "Zuo J.L."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/pages | "158-167"xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/title | "MCP-1 stimulates spinal microglia via PI3K/Akt pathway in bone cancer pain."xsd:string |
| http://purl.uniprot.org/citations/25555372 | http://purl.uniprot.org/core/volume | "1599"xsd:string |
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