| http://purl.uniprot.org/citations/25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25555806 | http://www.w3.org/2000/01/rdf-schema#comment | "Although glial cell line-derived neurotrophic factor (GDNF)/Ret signaling is essential for enteric nervous system (ENS) development, the positive regulators regulating GDNF/Ret signaling and controlling ENS development are poorly understood. Here, we show that Nedd4-related E3 ubiquitin ligase-2 (NEDL2) plays an essential and positive physiological role in regulating ENS development and GDNF/Ret signaling. All of the NEDL2-deficient mice die within 2weeks after birth, showing low body weight. These mice showed a progressive bowel motility defect resulting from intestinal aganglionosis. We show that NEDL2 positively regulates enteric neural precursor proliferation through the GDNF/Akt signaling pathway. Together, these findings unveil the physiological function of NEDL2 in vivo."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2014.12.013"xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Wang S."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Xing G."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Qiu X."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Wei R."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/author | "Lu K."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/pages | "578-586"xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/title | "NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling."xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/25555806 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25555806 |
| http://purl.uniprot.org/citations/25555806 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25555806 |
| http://purl.uniprot.org/uniprot/#_D3Z783-mappedCitation-25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555806 |
| http://purl.uniprot.org/uniprot/#_D3YYP9-mappedCitation-25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555806 |
| http://purl.uniprot.org/uniprot/#_D3Z1Z4-mappedCitation-25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555806 |
| http://purl.uniprot.org/uniprot/#_D3YXX3-mappedCitation-25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555806 |
| http://purl.uniprot.org/uniprot/#_P15331-mappedCitation-25555806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555806 |