| http://purl.uniprot.org/citations/25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25555992 | http://www.w3.org/2000/01/rdf-schema#comment | "A devastating aspect of cancer cachexia is severe loss of muscle and fat mass. Though cachexia occurs in both sexes, it is not well-defined in the female. The Apc(Min/+) mouse is genetically predisposed to develop intestinal tumors; circulating IL-6 is a critical regulator of cancer cachexia in the male Apc(Min/+) mouse. The purpose of this study was to examine the relationship between IL-6 signaling and cachexia progression in the female Apc(Min/+) mouse. Male and female Apc(Min/+) mice were examined during the initiation and progression of cachexia. Another group of females had IL-6 overexpressed between 12 and 14 weeks or 15-18 weeks of age to determine whether IL-6 could induce cachexia. Cachectic female Apc(Min/+) mice lost body weight, muscle mass, and fat mass; increased muscle IL-6 mRNA expression was associated with these changes, but circulating IL-6 levels were not. Circulating IL-6 levels did not correlate with downstream signaling in muscle in the female. Muscle IL-6r mRNA expression and SOCS3 mRNA expression as well as muscle IL-6r protein and STAT3 phosphorylation increased with severe cachexia in both sexes. Muscle SOCS3 protein increased in cachectic females but decreased in cachectic males. IL-6 overexpression did not affect cachexia progression in female Apc(Min/+) mice. Our results indicate that female Apc(Min/+) mice undergo cachexia progression that is at least initially IL-6-independent. Future studies in the female will need to determine mechanisms underlying regulation of IL-6 response and cachexia induction."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2014.12.015"xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Davis J.M."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Carson J.A."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Hardee J.P."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Puppa M.J."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Hetzler K.L."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/author | "Narsale A.A."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/pages | "816-825"xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/title | "Sex differences in the relationship of IL-6 signaling to cancer cachexia progression."xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://purl.uniprot.org/core/volume | "1852"xsd:string |
| http://purl.uniprot.org/citations/25555992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25555992 |
| http://purl.uniprot.org/citations/25555992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25555992 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF4-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2JFG1-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JFT1-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |
| http://purl.uniprot.org/uniprot/#_A2RTD1-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |
| http://purl.uniprot.org/uniprot/#_B2RUG9-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |
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| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-25555992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25555992 |