| http://purl.uniprot.org/citations/25557550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25557550 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA-mediated gene silencing in human cells requires the accurate generation of ∼22 nt microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer. Although the phylogenetically conserved RNA-binding proteins TRBP and PACT are known to contribute to this process, their mode of Dicer binding and their genome-wide effects on miRNA processing have not been determined. We solved the crystal structure of the human Dicer-TRBP interface, revealing the structural basis of the interaction. Interface residues conserved between TRBP and PACT show that the proteins bind to Dicer in a similar manner and by mutual exclusion. Based on the structure, a catalytically active Dicer that cannot bind TRBP or PACT was designed and introduced into Dicer-deficient mammalian cells, revealing selective defects in guide strand selection. These results demonstrate the role of Dicer-associated RNA binding proteins in maintenance of gene silencing fidelity."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2014.11.030"xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Doudna J.A."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Wilson R.C."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Noland C.L."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Kidwell M.A."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Schneider C.P."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/author | "Tambe A."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/pages | "397-407"xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/title | "Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis."xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/25557550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25557550 |
| http://purl.uniprot.org/citations/25557550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25557550 |
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