| http://purl.uniprot.org/citations/25558062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25558062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25558062 | http://www.w3.org/2000/01/rdf-schema#comment | "G protein-coupled receptor 124 (GPR124) is an orphan receptor in the adhesion family of GPCRs, and previous global or endothelial-specific disruption of Gpr124 in mice led to defective CNS angiogenesis and blood-brain barriergenesis. Similar developmental defects were observed following dual deletion of Wnt7a/Wnt7b or deletion of β-catenin in endothelial cells, suggesting a possible relationship between GPR124 and canonical WNT signaling. Here, we show using in vitro reporter assays, mutation analysis, and genetic interaction studies in vivo that GPR124 functions as a WNT7A/WNT7B-specific costimulator of β-catenin signaling in brain endothelium. WNT7-stimulated β-catenin signaling was dependent upon GPR124's intracellular PDZ binding motif and a set of leucine-rich repeats in its extracellular domain. This study reveals a vital role for GPR124 in potentiation of WNT7-induced canonical β-catenin signaling with important implications for understanding and manipulating CNS-specific angiogenesis and blood-brain barrier-genesis."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.12.020"xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2014.12.020"xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Wu B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Shukla A."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Shukla A."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Hilton M.B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Hilton M.B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Morris H."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Morris H."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Seaman S."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Seaman S."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "St Croix B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "St Croix B."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Posokhova E."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Posokhova E."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Rubin J.S."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Rubin J.S."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Swing D.A."xsd:string |
| http://purl.uniprot.org/citations/25558062 | http://purl.uniprot.org/core/author | "Swing D.A."xsd:string |