| http://purl.uniprot.org/citations/25561801 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25561801 | http://www.w3.org/2000/01/rdf-schema#comment | "AimTo investigate the expression of zinc finger protein 139 (ZNF139) in gastric cancer (GC), and to analyze its clinical significance.MethodsA total of 108 patients who were diagnosed with GC and underwent surgery between January 2005 and March 2007 were enrolled in this study. Gastric tumor specimens and paired tumor-adjacent tissues were collected and paraffin-embedded, and the clinicopathologic characteristics and prognosis were recorded. The expression of ZNF139, Bcl-2, Bax, and caspase-3 were determined by immunohistochemistry, and apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. SPSS 13.0 software was used for data processing and analyses, and significance was determined at P < 0.05.ResultsThe expression of ZNF139 was stronger in tumors than in tumor-adjacent tissues (66.67% vs 44.44%; P < 0.01). Overexpression of ZNF139 correlated with tumor differentiation, invasion depth, clinical stage, lymphatic metastasis, and blood vessel invasion (all Ps < 0.05). Patients with overexpression of ZNF139 had a poorer prognosis (P < 0.01), and overexpression of ZNF139 was an independent factor for the prognosis of GC patients by a Cox survival analysis (P = 0.02). A negative relationship between ZNF139 and the apoptosis index was observed (r = -0.686; P < 0.01). The expression of Bcl-2 in GC was stronger than in tumor-adjacent tissues (66.67% vs 41.67%), whereas the expression levels of Bax and caspase-3 were lower in primary tumors (54.63% and 47.22%, respectively) than in tumor-adjacent tissues (73.15% and 73.15%, respectively) (all Ps < 0.05). The expression of ZNF139 negatively correlated with caspase-3 (r = -0.370; P < 0.01). The expressions of Bcl-2 and Bax were also negatively correlated (r = -0.231; P = 0.02). The expressions of caspase-3 and Bax protein were positively correlated (r = 0.217; P = 0.024).ConclusionZNF139 is related to clinicopathologic characteristics and prognosis of GC. Furthermore, it is overexpressed and involved in apoptosis in GC tissues by regulating caspase-3."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.org/dc/terms/identifier | "doi:10.3748/wjg.v20.i48.18346"xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Wang L.L."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Fan L.Q."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Tan B.B."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/author | "Leng Y.L."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/name | "World J Gastroenterol"xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/pages | "18346-18353"xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/title | "Zinc finger protein 139 expression in gastric cancer and its clinical significance."xsd:string |
| http://purl.uniprot.org/citations/25561801 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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