| http://purl.uniprot.org/citations/25564224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25564224 | http://www.w3.org/2000/01/rdf-schema#comment | "Evidence is accumulating for the existence of a signal transducer and activator of transcription 2 (STAT2)/interferon regulatory factor 9 (IRF9)-dependent, STAT1-independent interferon alpha (IFNα) signalling pathway. However, no detailed insight exists into the genome-wide transcriptional regulation and the biological implications of STAT2/IRF9-dependent IFNα signalling as compared with interferon-stimulated gene factor 3 (ISGF3). In STAT1-defeicient U3C cells stably overexpressing human STAT2 (hST2-U3C) and STAT1-deficient murine embryonic fibroblast cells stably overexpressing mouse STAT2 (mST2-MS1KO) we observed that the IFNα-induced expression of 2'-5'-oligoadenylate synthase 2 (OAS2) and interferon-induced protein with tetratricopeptide repeats 1 (Ifit1) correlated with the kinetics of STAT2 phosphorylation, and the presence of a STAT2/IRF9 complex requiring STAT2 phosphorylation and the STAT2 transactivation domain. Subsequent microarray analysis of IFNα-treated wild-type (WT) and STAT1 KO cells overexpressing STAT2 extended our observations and identified ∼120 known antiviral ISRE-containing interferon-stimulated genes (ISGs) commonly up-regulated by STAT2/IRF9 and ISGF3. The STAT2/IRF9-directed expression profile of these IFN-stimulated genes (ISGs) was prolonged as compared with the early and transient response mediated by ISGF3. In addition, we identified a group of 'STAT2/IRF9-specific' ISGs, whose response to IFNα was ISGF3-independent. Finally, STAT2/IRF9 was able to trigger an antiviral response upon encephalomyocarditis virus (EMCV) and vesicular stomatitis Indiana virus (VSV). Our results further prove that IFNα-activated STAT2/IRF9 induces a prolonged ISGF3-like transcriptome and generates an antiviral response in the absence of STAT1. Moreover, the existence of 'STAT2/IRF9-specific' target genes predicts a novel role of STAT2 in IFNα signalling."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20140644"xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Chen Y.L."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Lee C.K."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Wesoly J."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Bluyssen H.A."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Blaszczyk K."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Balint B.L."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Chmielewski S."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Nowicka H."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Olejnik A."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Kostyrko K."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/author | "Ozgyin L."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/pages | "511-524"xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/title | "STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1."xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://purl.uniprot.org/core/volume | "466"xsd:string |
| http://purl.uniprot.org/citations/25564224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25564224 |
| http://purl.uniprot.org/citations/25564224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25564224 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-25564224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25564224 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-25564224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25564224 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-25564224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25564224 |
| http://purl.uniprot.org/uniprot/#_E9PZJ2-mappedCitation-25564224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25564224 |