| http://purl.uniprot.org/citations/25564762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25564762 | http://www.w3.org/2000/01/rdf-schema#comment | "The conserved phosphatidylserine receptor (PSR) was first identified as a receptor for phosphatidylserine, an 'eat-me' signal exposed by apoptotic cells. However, several studies suggest that PSR may also act as an arginine demethylase, a lysyl hydroxylase, or an RNA-binding protein through its N-terminal JmjC domain. How PSR might execute drastically different biochemical activities, and whether they are physiologically significant, remain unclear. Here we report that a lysine-rich motif in the extracellular domain of PSR-1, the Caenorhabditis elegans PSR, mediates specific phosphatidylserine binding in vitro and clearance of apoptotic cells in vivo. This motif also mediates phosphatidylserine-induced oligomerization of PSR-1, suggesting a mechanism by which PSR-1 activates phagocytosis. Mutations in the phosphatidylserine-binding motif, but not in its Fe(II) binding site critical for the JmjC activity, abolish PSR-1 phagocytic function. Moreover, PSR-1 enriches and clusters around apoptotic cells during apoptosis. These results establish that PSR-1 is a conserved, phosphatidylserine-recognizing phagocyte receptor."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6717"xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Liang Q."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Yuan Q."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Xia N.S."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Chen Y.Z."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Driscoll M."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Godfroy J.I."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/author | "Ann Royal M."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/pages | "5717"xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/title | "A lysine-rich motif in the phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells."xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25564762 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25564762 |
| http://purl.uniprot.org/citations/25564762 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25564762 |