| http://purl.uniprot.org/citations/2556704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2556704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2556704 | http://www.w3.org/2000/01/rdf-schema#comment | "Two types (I and II) of cDNAs encoding the large (A) subunit of calcineurin, a calmodulin-regulated protein phosphatase, were isolated from human basal ganglia and brainstem mRNA. The complete sequences of the two calcineurin clones are identical except for a 54-base-pair insert in the type I clone and different 3' ends including part of the coding sequence for the C termini of the two proteins. These findings suggest that calcineurin A consists of at least two isozymes that may result from alternative splicing events. The two forms of the enzyme differ in the C terminus, which contains an inhibitory domain rapidly severed by limited proteolysis. With the exception of an 18-amino acid insert, the central parts of the molecules, which harbor the catalytic domains, are identical and show extended similarities with the entire catalytic subunits of protein phosphatases 1 and 2A, defining a distinct family of protein phosphatases. The 40-residue N-terminal fragment, specific for calcineurin, contains a sequence of 11 successive prolines that is also found in bovine brain calcineurin by peptide sequencing. A role in the calmodulin activation of calcineurin is proposed for this novel structural element."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.86.23.9183"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.86.23.9183"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/author | "Guerini D."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/author | "Guerini D."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/author | "Klee C.B."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/author | "Klee C.B."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/pages | "9183-9187"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/pages | "9183-9187"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/title | "Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/title | "Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain."xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/2556704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2556704 |
| http://purl.uniprot.org/citations/2556704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2556704 |
| http://purl.uniprot.org/citations/2556704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2556704 |
| http://purl.uniprot.org/citations/2556704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2556704 |
| http://purl.uniprot.org/uniprot/P16298 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2556704 |
| http://purl.uniprot.org/uniprot/Q08209#attribution-123E8F85CE8B35D5A60B02CBCB26A6DF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2556704 |