| http://purl.uniprot.org/citations/25567280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25567280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25567280 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Citation |
| http://purl.uniprot.org/citations/25567280 | http://www.w3.org/2000/01/rdf-schema#comment | "Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.org/dc/terms/identifier | "doi:10.1038/NATURE13995"xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature13995"xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Davies G.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Davies G.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Gilbert H.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Gilbert H.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Martens E.C."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Martens E.C."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Williams S.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Williams S.J."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Boraston A.B."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Boraston A.B."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Pudlo N.A."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Pudlo N.A."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Urs K."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Urs K."xsd:string |
| http://purl.uniprot.org/citations/25567280 | http://purl.uniprot.org/core/author | "Suits M.D."xsd:string |