| http://purl.uniprot.org/citations/25567286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25567286 | http://www.w3.org/2000/01/rdf-schema#comment | "Functional regeneration after nervous system injury requires transected axons to reconnect with their original target tissue. Axonal fusion, a spontaneous regenerative mechanism identified in several species, provides an efficient means of achieving target reconnection as a regrowing axon is able to contact and fuse with its own separated axon fragment, thereby re-establishing the original axonal tract. Here we report a molecular characterization of this process in Caenorhabditis elegans, revealing dynamic changes in the subcellular localization of the EFF-1 fusogen after axotomy, and establishing phosphatidylserine (PS) and the PS receptor (PSR-1) as critical components for axonal fusion. PSR-1 functions cell-autonomously in the regrowing neuron and, instead of acting in its canonical signalling pathway, acts in a parallel phagocytic pathway that includes the transthyretin protein TTR-52, as well as CED-7, NRF-5 and CED-6 (refs 9, 10, 11, 12). We show that TTR-52 binds to PS exposed on the injured axon, and can restore fusion several hours after injury. We propose that PS functions as a 'save-me' signal for the distal fragment, allowing conserved apoptotic cell clearance molecules to function in re-establishing axonal integrity during regeneration of the nervous system."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature14102"xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Nakagawa A."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Neumann B."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Xue D."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Lee E.S."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Coakley S."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Hilliard M.A."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Linton C."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/author | "Giordano-Santini R."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/pages | "219-222"xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/title | "EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway."xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://purl.uniprot.org/core/volume | "517"xsd:string |
| http://purl.uniprot.org/citations/25567286 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25567286 |
| http://purl.uniprot.org/citations/25567286 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25567286 |
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| http://purl.uniprot.org/uniprot/#_P34358-mappedCitation-25567286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567286 |
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| http://purl.uniprot.org/uniprot/#_G5EBM0-mappedCitation-25567286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567286 |
| http://purl.uniprot.org/uniprot/#_G5ECA1-mappedCitation-25567286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567286 |
| http://purl.uniprot.org/uniprot/#_Q27GT3-mappedCitation-25567286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567286 |