| http://purl.uniprot.org/citations/25567989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25567989 | http://www.w3.org/2000/01/rdf-schema#comment | "The LIN-1 ETS transcription factor plays a pivotal role in controlling cell fate decisions during development of the Caenorhabditis elegans vulva. Prior to activation of the RTK/Ras/ERK-signaling pathway, LIN-1 functions as a SUMOylated transcriptional repressor that inhibits vulval cell fate. Here we demonstrate using the yeast two-hybrid system that SUMOylation of LIN-1 mediates interactions with a protein predicted to be involved in transcriptional repression: the RAD-26 Mi-2β/CHD4 component of the nucleosome remodeling and histone deacetylation (NuRD) transcriptional repression complex. Genetic studies indicated that rad-26 functions to inhibit vulval cell fates in worms. Using the yeast two-hybrid system, we showed that the EGL-27/MTA1 component of the NuRD complex binds the carboxy-terminus of LIN-1 independently of LIN-1 SUMOylation. EGL-27 also binds UBC-9, an enzyme involved in SUMOylation, and MEP-1, a zinc-finger protein previously shown to bind LIN-1. Genetic studies indicate that egl-27 inhibits vulval cell fates in worms. These results suggest that LIN-1 recruits multiple proteins that repress transcription via both the SUMOylated amino-terminus and the unSUMOylated carboxy-terminus. Assays in cultured cells showed that the carboxy-terminus of LIN-1 was converted to a potent transcriptional activator in response to active ERK. We propose a model in which LIN-1 recruits multiple transcriptional repressors to inhibit the 1° vulval cell fate, and phosphorylation by ERK converts LIN-1 to a transcriptional activator that promotes the 1° vulval cell fate."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.114.172668"xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Kornfeld K."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Murphy J.T."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Schneider D.L."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Herman M.A."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Ratliff T.M."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Pepin D."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Mohammad D.H."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Leight E.R."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/author | "Fantz D.A."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/pages | "761-775"xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/title | "Conversion of the LIN-1 ETS protein of Caenorhabditis elegans from a SUMOylated transcriptional repressor to a phosphorylated transcriptional activator."xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://purl.uniprot.org/core/volume | "199"xsd:string |
| http://purl.uniprot.org/citations/25567989 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25567989 |
| http://purl.uniprot.org/citations/25567989 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25567989 |
| http://purl.uniprot.org/uniprot/Q09228#attribution-7D91C0286182041FC3D1A0412B3AA654 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25567989 |
| http://purl.uniprot.org/uniprot/Q18241#attribution-164D3DBCD46BFC393040AAF936BF86FB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25567989 |
| http://purl.uniprot.org/uniprot/Q18241#attribution-5EB0EFF6DCB8A0DC25FA089329CD5D51 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25567989 |
| http://purl.uniprot.org/uniprot/Q18241#attribution-7D91C0286182041FC3D1A0412B3AA654 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25567989 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUG2-mappedCitation-25567989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567989 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AUG7-mappedCitation-25567989 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25567989 |