| http://purl.uniprot.org/citations/25568082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25568082 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs repress mRNA translation by guiding Argonaute proteins to partially complementary binding sites, primarily within the 3' untranslated region (UTR) of target mRNAs. In cell lines, Argonaute-bound microRNAs exist mainly in high molecular weight RNA-induced silencing complexes (HMW-RISC) associated with target mRNA. Here we demonstrate that most adult tissues contain reservoirs of microRNAs in low molecular weight RISC (LMW-RISC) not bound to mRNA, suggesting that these microRNAs are not actively engaged in target repression. Consistent with this observation, the majority of individual microRNAs in primary T cells were enriched in LMW-RISC. During T-cell activation, signal transduction through the phosphoinositide-3 kinase-RAC-alpha serine/threonine-protein kinase-mechanistic target of rapamycin pathway increased the assembly of microRNAs into HMW-RISC, enhanced expression of the glycine-tryptophan protein of 182 kDa, an essential component of HMW-RISC, and improved the ability of microRNAs to repress partially complementary reporters, even when expression of targeting microRNAs did not increase. Overall, data presented here demonstrate that microRNA-mediated target repression in nontransformed cells depends not only on abundance of specific microRNAs, but also on regulation of RISC assembly by intracellular signaling."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1424217112"xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Spraggon L."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Lindsten T."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Gonzalez A.J."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Briskin D."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Ventura A."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Vidigal J.A."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "La Rocca G."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Leslie C.S."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "DeMatteo R.G."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Olejniczak S.H."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/author | "Radler M.R."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/pages | "767-772"xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/title | "In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA."xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/25568082 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25568082 |
| http://purl.uniprot.org/citations/25568082 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25568082 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPB4-mappedCitation-25568082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25568082 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPF5-mappedCitation-25568082 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25568082 |