| http://purl.uniprot.org/citations/25573187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25573187 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae cells respond to hypotonic stress (HTS) by a cytosolic calcium rise, either generated by an influx of calcium from extracellular medium, when calcium is available, or by a release from intracellular stores in scarcity of extracellular calcium. Calcium release from intracellular compartments is peculiarly inhibited by external calcium in a calcineurin-independent and Cch1-, but not Mid1-, driven manner. HTS-induced calcium release is also negatively regulated by the ER protein Cls2 and involves a poorly characterized protein, FLC2/YAL053W gene product, previously proposed to be required for FAD transport in the ER, albeit, due to its molecular features, it was also previously classified as an ion transporter. A computational analysis revealed that this gene and its three homologs in S. cerevisiae, together with previously identified Schizosaccharomyces pombe pkd2 and Neurospora crassa calcium-related spray protein, belong to a fungal branch of TRP-like ion transporters related to human mucolipin and polycystin 2 calcium transporters. Moreover, disruption of FLC2 gene confers severe sensitivity to Calcofluor white and hyper-activation of the cell wall integrity MAPK cascade, suggesting a role in cell wall maintenance as previously suggested for the fission yeast homolog. Perturbation in cytosolic resting calcium concentration and hyper-activation of calcineurin in exponentially growing cells suggest a role for this transporter in calcium homeostasis in yeast."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ceca.2014.12.003"xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Martegani E."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Ambrosini R."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Tisi R."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Filippi G."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Belotti F."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Groppi S."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/author | "Rigamonti M."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/name | "Cell Calcium"xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/pages | "57-68"xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/title | "Hypotonic stress-induced calcium signaling in Saccharomyces cerevisiae involves TRP-like transporters on the endoplasmic reticulum membrane."xsd:string |
| http://purl.uniprot.org/citations/25573187 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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