| http://purl.uniprot.org/citations/25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25573755 | http://www.w3.org/2000/01/rdf-schema#comment | "Water channel aquaporin-1 (AQP1) is expressed at epithelial cell plasma membranes in renal proximal tubules and thin descending limb of Henle. Recently, AQP1 was reported to interact with β-catenin. Here we investigated the relationship between AQP1 and Wnt signaling in in vitro and in vivo models of autosomal dominant polycystic kidney disease (PKD). AQP1 overexpression decreased β-catenin and cyclinD1 expression, suggesting down-regulation of Wnt signaling, and coimmunoprecipitation showed AQP1 interaction with β-catenin, glycogen synthase kinase 3β, LRP6, and Axin1. AQP1 inhibited cyst development and promoted branching in matrix-grown MDCK cells. In embryonic kidney cultures, AQP1 deletion increased cyst development by up to ∼ 40%. Kidney size and cyst number were significantly greater in AQP1-null PKD mice than in AQP1-expressing PKD mice, with the difference mainly attributed to a greater number of proximal tubule cysts. Biochemical analysis revealed decreased β-catenin phosphorylation and increased β-catenin expression in AQP1-null PKD mice, suggesting enhanced Wnt signaling. These results implicate AQP1 as a novel determinant in renal cyst development that may involve inhibition of Wnt signaling by an AQP1-macromolecular signaling complex."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.14-260828"xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Lei T."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Zhou H."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Xia Y."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Lei L."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/author | "Verkman A.S."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/pages | "1551-1563"xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/title | "Aquaporin-1 retards renal cyst development in polycystic kidney disease by inhibition of Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/25573755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25573755 |
| http://purl.uniprot.org/citations/25573755 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25573755 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRP8-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRZ6-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPP4-mappedCitation-25573755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25573755 |