| http://purl.uniprot.org/citations/25574025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25574025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25574025 | http://www.w3.org/2000/01/rdf-schema#comment | "XRCC4 and XLF are two structurally related proteins that function in DNA double-strand break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called C9orf142) as a new XRCC4 superfamily member and show that its crystal structure resembles that of XRCC4. PAXX interacts directly with the DSB-repair protein Ku and is recruited to DNA-damage sites in cells. Using RNA interference and CRISPR-Cas9 to generate PAXX(-/-) cells, we demonstrate that PAXX functions with XRCC4 and XLF to mediate DSB repair and cell survival in response to DSB-inducing agents. Finally, we reveal that PAXX promotes Ku-dependent DNA ligation in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chromatin in cells. These findings identify PAXX as a new component of the NHEJ machinery."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1261971"xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1261971"xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Robinson C.V."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Tamura N."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Tamura N."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Blundell T.L."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Blundell T.L."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Mehmood S."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Mehmood S."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Ochi T."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Ochi T."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Blackford A.N."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Blackford A.N."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Coates J."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Coates J."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Draviam V.M."xsd:string |
| http://purl.uniprot.org/citations/25574025 | http://purl.uniprot.org/core/author | "Draviam V.M."xsd:string |