| http://purl.uniprot.org/citations/25578648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25578648 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked inhibitor of apoptosis (XIAP) is a protein that possesses anti-apoptotic function and dysregulation of it has been linked to a number human disease such as cancers and neurodegenerative disorders. In our previous study, we have found that nitric oxide (NO) can modulate the anti-apoptotic function of XIAP and found that this can contribute to the pathogenesis of Parkinson's disease. Specifically, we found that modification of baculoviral IAP repeat 2 of XIAP by S-nitrosylation can compromise XIAP's anti-caspase 3 and anti-apoptotic function. In this study, we report that cysteine (Cys) 90, Cys 213 and Cys 327 can be specifically S-nitrosylated by NO. We found that mutations of Cys 90 and Cys 327 affect the normal structure of XIAP. More importantly, we found that S-nitrosylation of XIAP Cys 213 impairs the anti-caspase 3 and anti-apoptotic function of XIAP that we observed in our previous study."xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10495-015-1087-3"xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/author | "Chung K.K."xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/author | "Wan O.W."xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/name | "Apoptosis"xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/pages | "491-499"xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/title | "S-nitrosylation of XIAP at Cys 213 of BIR2 domain impairs XIAP's anti-caspase 3 activity and anti-apoptotic function."xsd:string |
| http://purl.uniprot.org/citations/25578648 | http://purl.uniprot.org/core/volume | "20"xsd:string |
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