| http://purl.uniprot.org/citations/25584796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25584796 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion of ERG (Erg(iEC-KO)) results in defective physiological and pathological angiogenesis in the postnatal retina and tumors, with decreased vascular stability. ERG controls the Wnt/β-catenin pathway by promoting β-catenin stability, through signals mediated by VE-cadherin and the Wnt receptor Frizzled-4. Wnt signaling is decreased in ERG-deficient endothelial cells; activation of Wnt signaling with lithium chloride, which stabilizes β-catenin levels, corrects vascular defects in Erg(cEC-KO) embryos. Finally, overexpression of ERG in vivo reduces permeability and increases stability of VEGF-induced blood vessels. These data demonstrate that ERG is an essential regulator of angiogenesis and vascular stability through Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2014.11.016"xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Aspalter I.M."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Gottgens B."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Gerhardt H."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Dejana E."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Adams R.H."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Khan S.T."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Dufton N."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Randi A.M."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Mason J.C."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Birdsey G.M."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Hodivala-Dilke K."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Reynolds L.E."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Shah A.V."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/author | "Osuna Almagro L."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/pages | "82-96"xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/title | "The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/25584796 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25584796 |
| http://purl.uniprot.org/citations/25584796 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25584796 |