| http://purl.uniprot.org/citations/25588303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25588303 | http://www.w3.org/2000/01/rdf-schema#comment | "The Enhancer of split complex [E(spl)-C] comprises twelve genes of different classes. Seven genes encode proteins of with a basic-helix-loop-helix-orange (bHLH-O) domain that function as transcriptional repressors and serve as effectors of the Notch signalling pathway. They have been named E(spl)m8-, m7-, m5-, m3-, mβ-, mγ- and mδ-HLH. Four genes, E(spl)m6-, m4-, m2- and mα-BFM are intermingled and encode Notch repressor proteins of the Bearded-family (BFM). The complex is split by a single gene of unrelated function, encoding a Kazal-type protease inhibitor (Kaz-m1). All members within a family, bHLH-O or BFM, are very similar in structure and in function. In an attempt to generate specific mutants, we have mobilised P-element constructs residing next to E(spl)m7-HLH and E(spl)mγ-HLH, respectively. The resulting deletions were mapped molecularly and by cytology. Two small deletions affected only E(spl)m7-HLH and E(spl)mδ. The deficient flies were viable without apparent phenotype. Larger deletions, generated also by X-ray mutagenesis, uncover most of the E(spl)-C. The phenotypes of homozygous deficient embryos were analysed to characterize the respective loss of Notch signalling activity."xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.org/dc/terms/identifier | "doi:10.1111/hrd2.00065"xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/author | "Wurmbach E."xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/author | "Preiss A."xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/name | "Hereditas"xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/pages | "159-168"xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/title | "Deletion mapping in the Enhancer of split complex."xsd:string |
| http://purl.uniprot.org/citations/25588303 | http://purl.uniprot.org/core/volume | "151"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KH50-mappedCitation-25588303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25588303 |
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| http://purl.uniprot.org/uniprot/#_O01398-mappedCitation-25588303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25588303 |
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| http://purl.uniprot.org/uniprot/#_O97176-mappedCitation-25588303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25588303 |
| http://purl.uniprot.org/uniprot/#_O97177-mappedCitation-25588303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25588303 |