| http://purl.uniprot.org/citations/25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25594181 | http://www.w3.org/2000/01/rdf-schema#comment | "The universally conserved GTPase elongation factor G (EF-G) catalyzes the translocation of tRNA and mRNA on the ribosome after peptide bond formation. Despite numerous studies suggesting that EF-G undergoes extensive conformational rearrangements during translocation, high-resolution structures exist for essentially only one conformation of EF-G in complex with the ribosome. Here, we report four atomic-resolution crystal structures of EF-G bound to the ribosome programmed in the pre- and posttranslocational states and to the ribosome trapped by the antibiotic dityromycin. We observe a previously unseen conformation of EF-G in the pretranslocation complex, which is independently captured by dityromycin on the ribosome. Our structures provide insights into the conformational space that EF-G samples on the ribosome and reveal that tRNA translocation on the ribosome is facilitated by a structural transition of EF-G from a compact to an elongated conformation, which can be prevented by the antibiotic dityromycin."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2014.11.049"xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/author | "Steitz T.A."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/author | "Bulkley D."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/author | "Gagnon M.G."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/pages | "219-227"xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/title | "Conformational changes of elongation factor G on the ribosome during tRNA translocation."xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://purl.uniprot.org/core/volume | "160"xsd:string |
| http://purl.uniprot.org/citations/25594181 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25594181 |
| http://purl.uniprot.org/citations/25594181 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25594181 |
| http://purl.uniprot.org/uniprot/#_P35871-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P0DOY6-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P0DOY9-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P17291-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P80339-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P80340-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P80371-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P80372-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |
| http://purl.uniprot.org/uniprot/#_P80373-mappedCitation-25594181 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25594181 |