| http://purl.uniprot.org/citations/25595785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25595785 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-31 is a key mediator of itching in atopic dermatitis (AD) and is preferentially produced by activated CD4(+) T cells and Th2 cells. Although pathophysiological functions of IL-31 have been suggested in diverse immune disorders, the molecular events underlying IL-31 gene regulation are still unclear. In this study we identified the transcription start site and functional promoter involved in IL-31 gene regulation in mouse CD4(+) T cells. TCR stimulation-dependent IL-31 expression was found to be closely linked with in vivo binding of NFAT1 and JunB to the IL-31 promoter. Although NFAT1 alone enhanced IL-31 promoter activity, it was further enhanced in the presence of JunB. Conversely, knockdown of either NFAT1 or JunB resulted in reduced IL-31 expression. NFAT1-deficient CD4(+) T cells showed a significant defect in IL-31 expression compared with wild-type CD4(+) T cells. In agreement with these findings, mice subjected to atopic conditions showed much higher levels of IL-31, which were closely correlated with a significant increase in the number of infiltrated NFAT1(+)CD4(+) T cells into the AD ears. Amelioration of AD progression by cyclosporin A treatment was well correlated with downregulation of IL-31 expressions in CD4(+) T cells and total ear residual cells. In summary, our results suggest a functional cooperation between NFAT1 and JunB in mediating IL-31 gene expression in CD4(+) T cells and indicate that interference with this interaction or their activity has the potential of reducing IL-31-mediated AD symptoms."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1401862"xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Kim J.E."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Park E."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Hwang J.S."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Hwang W."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Hwang S.M."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Wang H.S."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Im S.H."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Jun C.D."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Chae C.S."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Rudra D."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/author | "Kim G.C."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/pages | "1963-1974"xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/title | "NFAT1 and JunB cooperatively regulate IL-31 gene expression in CD4+ T cells in health and disease."xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/25595785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25595785 |
| http://purl.uniprot.org/citations/25595785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25595785 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-25595785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25595785 |
| http://purl.uniprot.org/uniprot/#_B5B2P6-mappedCitation-25595785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25595785 |
| http://purl.uniprot.org/uniprot/#_B5B2P7-mappedCitation-25595785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25595785 |