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| http://purl.uniprot.org/citations/25595912 | http://www.w3.org/2000/01/rdf-schema#comment | "The PAX5 gene is altered in 30% of BCP-ALL patients and PAX5 chromosomal translocations account for 2-3% of cases. Although PAX5 fusion genes significantly affect the transcription of PAX5 target genes, their role in sustaining leukemia cell survival is poorly understood. In an in vitro model of PAX5/ETV6 leukemia, we demonstrated that Lck hyper-activation, and down-regulation of its negative regulator Csk, lead to STAT5 hyper-activation and consequently to the up-regulation of the downstream effectors, cMyc and Ccnd2. More important, cells from PAX5 translocated patients show LCK up-regulation and over-activation, as well as STAT5 hyper-phosphorylation, compared to PAX5 wt and PAX5 deleted cases. As in BCR/ABL1 positive ALL, the hyper-activation of STAT5 pathway can represent a survival signal in PAX5 translocated cells, alternative to the pre-BCR, which is down-regulated. The LCK inhibitor BIBF1120 selectively reverts this phenomenon both in the murine model and in leukemic primary cells. LCK inhibitor could therefore represent a suitable candidate drug to target this subgroup of ALL patients."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.2807"xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Basso G."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "te Kronnie G."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Cazzaniga G."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Bardini M."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Biondi A."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Bugarin C."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Fazio G."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Giordan M."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/author | "Cazzaniga V."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/pages | "1569-1581"xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/title | "LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients."xsd:string |
| http://purl.uniprot.org/citations/25595912 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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