| http://purl.uniprot.org/citations/25596267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25596267 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied 1696 patients (18 to 61 years) with acute myeloid leukemia for ASXL1 mutations and identified these mutations in 103 (6.1%) patients. ASXL1 mutations were associated with older age (P<0.0001), male sex (P=0.041), secondary acute myeloid leukemia (P<0.0001), and lower values for bone marrow (P<0.0001) and circulating (P<0.0001) blasts. ASXL1 mutations occurred in all cytogenetic risk-groups; normal karyotype (40%), other intermediate-risk cytogenetics (26%), high-risk (24%) and low-risk (10%) cytogenetics. ASXL1 mutations were associated with RUNX1 (P<0.0001) and IDH2(R140) mutations (P=0.007), whereas there was an inverse correlation with NPM1 (P<0.0001), FLT3-ITD (P=0.0002), and DNMT3A (P=0.02) mutations. Patients with ASXL1 mutations had a lower complete remission rate (56% versus 74%; P=0.0002), and both inferior event-free survival (at 5 years: 15.9% versus 29.0%; P=0.02) and overall survival (at 5 years: 30.3% versus 45.7%; P=0.0004) compared to patients with wildtype ASXL1. In multivariable analyses, ASXL1 and RUNX1 mutation as a single variable did not have a significant impact on prognosis. However, we observed a significant interaction (P=0.04) for these mutations, in that patients with the genotype ASXL1(mutated)/RUNX1(mutated) had a higher risk of death (hazard ratio 1.8) compared to patients without this genotype. ASXL1 mutation, particularly in the context of a coexisting RUNX1 mutation, constitutes a strong adverse prognostic factor in acute myeloid leukemia."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.org/dc/terms/identifier | "doi:10.3324/haematol.2014.114157"xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Dohner K."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Brossart P."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Held G."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Bullinger L."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Dohner H."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Ringhoffer M."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Heuser M."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Ganser A."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Thol F."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Schlenk R.F."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Kindler T."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Nachbaur D."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Paschka P."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Gotze K."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Spath D."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Gaidzik V.I."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Kohne C.H."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Horst H.A."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Kundgen A."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Teleanu V."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Aulitzky T."xsd:string |
| http://purl.uniprot.org/citations/25596267 | http://purl.uniprot.org/core/author | "Herzig J.K."xsd:string |