| http://purl.uniprot.org/citations/25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25596532 | http://www.w3.org/2000/01/rdf-schema#comment | "Human hepatoma (HCC) has been reported to be strongly resistant to Fas-mediated apoptosis. However, the underlying mechanisms are poorly understood. In this study the function of oxysterol-binding protein-related protein 8 (ORP8) in human hepatoma cells apoptosis was assessed. We found that ORP8 is down-regulated, whereas miR-143, which controls ORP8 expression, is up-regulated in clinical HCC tissues as compared with liver tissue from healthy subjects. ORP8 overexpression triggered apoptosis in primary HCC cells and cell lines, which coincided with a relocation of cytoplasmic Fas to the cell plasma membrane and FasL up-regulation. Co-culture of HepG2 cells or primary HCC cells with Jurkat T-cells or T-cells, respectively, provided further evidence that ORP8 increases HCC cell sensitivity to Fas-mediated apoptosis. ORP8-induced Fas translocation is p53-dependent, and FasL was induced upon ORP8 overexpression via the endoplasmic reticulum stress response. Moreover, ORP8 overexpression and miR-143 inhibition markedly inhibited tumor growth in a HepG2 cell xenograft model. These results indicate that ORP8 induces HCC cell apoptosis through the Fas/FasL pathway. The role of ORP8 in Fas translocation to the plasma membrane and its down-regulation by miR-143 offer a putative mechanistic explanation for HCC resistance to apoptosis. ORP8 may be a potential target for HCC therapy."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.610188"xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Zhong W."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Zhu B."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Ye G."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Yi Q."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Yan D."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/author | "Pu M."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/pages | "8876-8887"xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/title | "Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/25596532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25596532 |
| http://purl.uniprot.org/citations/25596532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25596532 |
| http://purl.uniprot.org/uniprot/#_Q641R2-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |
| http://purl.uniprot.org/uniprot/#_L8ECJ0-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |
| http://purl.uniprot.org/uniprot/#_Q6ZME5-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |
| http://purl.uniprot.org/uniprot/#_Q96E43-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |
| http://purl.uniprot.org/uniprot/#_Q9BZF1-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |
| http://purl.uniprot.org/uniprot/#_Q5HYM3-mappedCitation-25596532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25596532 |