| http://purl.uniprot.org/citations/25597631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25597631 | http://www.w3.org/2000/01/rdf-schema#comment | "Plasma membrane budding of Atg-16L-positive vesicles represents a very early event in the generation of the phagophore and in the process of macroautophagy. Here we show that the membrane curvature-inducing protein annexin A2 contributes to the formation of these vesicles and their fusion to form phagophores. Ultrastructural, proteomic and FACS analyses of Atg16L-positive vesicles reveal that 30% of Atg16L-positive vesicles are also annexin A2-positive. Lipidomic analysis of annexin A2-deficient mouse cells indicates that this protein plays a role in recruiting phosphatidylserine and phosphatidylinositides to Atg16L-positive vesicles. Absence of annexin A2 reduces both vesicle formation and homotypic Atg16L vesicle fusion. Ultimately, a reduction in LC3 flux and dampening of macroautophagy are observed in dendritic cells from Anxa2(-/-) mice. Together, our analyses highlight the importance of annexin A2 in vesiculation of a population of Atg16L-positive structures from the plasma membrane, and in their homotypic fusion to form phagophore structures."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms6856"xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Diaz A."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Scharf B."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Cuervo A.M."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Sridhar S."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Hajjar K.A."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Santambrogio L."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Sidhar S."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Larocca J.N."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Clement C.C."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Morozova K."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Verzani Z."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/author | "Zolla V."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/pages | "5856"xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/title | "Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion."xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25597631 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25597631 |
| http://purl.uniprot.org/citations/25597631 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25597631 |
| http://purl.uniprot.org/uniprot/#_B0V2N5-mappedCitation-25597631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25597631 |
| http://purl.uniprot.org/uniprot/#_B0V2N7-mappedCitation-25597631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25597631 |
| http://purl.uniprot.org/uniprot/#_B0V2N8-mappedCitation-25597631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25597631 |