| http://purl.uniprot.org/citations/25599396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25599396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25599396 | http://www.w3.org/2000/01/rdf-schema#comment | "Aquarius is a multifunctional putative RNA helicase that binds precursor-mRNA introns at a defined position. Here we report the crystal structure of human Aquarius, revealing a central RNA helicase core and several unique accessory domains, including an ARM-repeat domain. We show that Aquarius is integrated into spliceosomes as part of a pentameric intron-binding complex (IBC) that, together with the ARM domain, cross-links to U2 snRNP proteins within activated spliceosomes; this suggests that the latter aid in positioning Aquarius on the intron. Aquarius's ARM domain is essential for IBC formation, thus indicating that it has a key protein-protein-scaffolding role. Finally, we provide evidence that Aquarius is required for efficient precursor-mRNA splicing in vitro. Our findings highlight the remarkable structural adaptations of a helicase to achieve position-specific recruitment to a ribonucleoprotein complex and reveal a new building block of the human spliceosome."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2951"xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2951"xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Urlaub H."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Urlaub H."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Luhrmann R."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Luhrmann R."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Pena V."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Pena V."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Bessonov S."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Bessonov S."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "De I."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "De I."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Hofele R."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Hofele R."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Will C.L."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "Will C.L."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "dos Santos K."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/author | "dos Santos K."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/25599396 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |