| http://purl.uniprot.org/citations/25599590 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25599590 | http://www.w3.org/2000/01/rdf-schema#comment | "Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations in HOIL1 (RBCK1) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency. We report that barrier-raised HOIL-1-deficient mice exhibit amylopectin-like deposits in the myocardium but show minimal signs of hyper-inflammation. However, they show immunodeficiency upon acute infection with Listeria monocytogenes, Toxoplasma gondii or Citrobacter rodentium. Increased susceptibility to Listeria was due to HOIL-1 function in hematopoietic cells and macrophages in production of protective cytokines. In contrast, HOIL-1-deficient mice showed enhanced control of chronic Mycobacterium tuberculosis or murine γ-herpesvirus 68 (MHV68), and these infections conferred a hyper-inflammatory phenotype. Surprisingly, chronic infection with MHV68 complemented the immunodeficiency of HOIL-1, IL-6, Caspase-1 and Caspase-1;Caspase-11-deficient mice following Listeria infection. Thus chronic herpesvirus infection generates signs of auto-inflammation and complements genetic immunodeficiency in mutant mice, highlighting the importance of accounting for the virome in genotype-phenotype studies."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.04494"xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Song C."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Virgin H.W."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Iwai K."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Boisson B."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Sibley L.D."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Carrero J.A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Israel A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Casanova J.L."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Kimmey J.M."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Stallings C.L."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Weiss L.A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Picard C."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "MacDuff D.A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Edelson B.T."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Reese T.A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Duan E."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Kambal A."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/author | "Laplantine E."xsd:string |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25599590 | http://purl.uniprot.org/core/name | "Elife"xsd:string |