| http://purl.uniprot.org/citations/25601761 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25601761 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of cytochrome P450 2J2 (CYP2J2) in cyclophosphamide (Cy) bioactivation was investigated in patients, cells and microsomes. Gene expression analysis showed that CYP2J2 mRNA expression was significantly (P<0.01) higher in 20 patients with hematological malignancies compared with healthy controls. CYP2J2 expression showed significant upregulation (P<0.05) during Cy treatment before stem cell transplantation. Cy bioactivation was significantly correlated to CYP2J2 expression. Studies in HL-60 cells expressing CYP2J2 showed reduced cell viability when incubated with Cy (half maximal inhibitory concentration=3.6 mM). Inhibition of CYP2J2 using telmisartan reduced Cy bioactivation by 50% and improved cell survival. Cy incubated with recombinant CYP2J2 microsomes has resulted in apparent Km and Vmax values of 3.7-6.6 mM and 2.9-10.3 pmol/(min·pmol) CYP, respectively. This is the first study demonstrating that CYP2J2 is equally important to CYP2B6 in Cy metabolism. The heart, intestine and urinary bladder express high levels of CYP2J2; local Cy bioactivation may explain Cy-treatment-related toxicities in these organs."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.org/dc/terms/identifier | "doi:10.1038/tpj.2014.82"xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Fares M."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Hassan M."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Abedi-Valugerdi M."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Terelius Y."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Moshfegh A."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Afsharian P."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "El-Serafi I."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/author | "Potacova Z."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/name | "Pharmacogenomics J"xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/pages | "405-413"xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/title | "Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies."xsd:string |
| http://purl.uniprot.org/citations/25601761 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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