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http://purl.uniprot.org/citations/25604476http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25604476http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Toll-like receptor (TLR) 2 can heterodimerise with TLR6 to detect diacylated lipoproteins. Hypoxia inducible factor-1 α co-ordinates selective induction of TLR2 and TLR6 during persistent hypoxia. We hypothesized that TLR 2/6 co-expression may be upregulated by chronic intermittent hypoxia with re-oxygenation (IHR) in obstructive sleep apnea (OSA).

Methods

TLR2/6 expressions on blood immune cells were measured in 144 patients with sleep-disordered breathing (SDB), including primary snoring (PS, n = 24), moderate to severe OSA (MSO, n = 60), very severe OSA (VSO, n = 36), and very severe OSA on continuous positive airway pressure (CPAP) treatment (VSOC, n = 24). An in vitro IHR experiment was also undertaken.

Results

Patients in both the MSO and VSO groups had increased TLR2/6 co-expression on CD16(+) neutrophil than those in the PS group. Patients in the VSOC group had reduced TLR2/6 co-expression on neutrophil than those in either the MSO or VSO group. Blood absolute neutrophil count was positively but weakly correlated with TLR2/6 co-expression on neutrophil. TLR2/6 co-expressions on both CD14(+) monocyte and CD3(+)CD4(+)T helper cell, and TLR2 expressions on both monocyte and T helper cell in SDB patients with low Minimum SaO₂ (≦70%) were all higher than those with high Minimum SaO₂. In vitro IHR for 1-4 days resulted in TLR2/6 co-upregulation on both neutrophil and monocyte.

Conclusions

OSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP treatment. In vitro IHR could induce TLR2/6 co-upregulation."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.org/dc/terms/identifier"doi:10.1007/s11325-014-1116-4"xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Chen C.J."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Chen Y.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Wang C.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Lin A.S."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Lin H.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Hsiao C.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Lin M.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Wang T.Y."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Liu S.F."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Liou C.W."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Huang K.T."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Su M.C."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/author"Chin C.H."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/name"Sleep Breath"xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/pages"873-882"xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/title"Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea."xsd:string
http://purl.uniprot.org/citations/25604476http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/25604476http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25604476
http://purl.uniprot.org/citations/25604476http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25604476
http://purl.uniprot.org/uniprot/#_D1CS91-mappedCitation-25604476http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25604476
http://purl.uniprot.org/uniprot/#_D1CS92-mappedCitation-25604476http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25604476
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